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Friday, November 20, 2009 |
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Roma
Aula Marotta - Istituto Superiore di Sanità, viale Regina Elena 299
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Begins at 09:30 |
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For information:
FONDAZIONE SIGMA-TAU
Viale Shakespeare, 47
00144 Rome
Tel. 06-59.26.443-4-5 06-59.26.600
Fax: 06-59.26.441 |
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MEDICINA DELLA COMPLESSITA' |
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"NETWORK PHARMACOLOGY: new models for developing drugs" |
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Looking for the molecular determinant of a certain disease (or, in any case, of the weak spot through which countering bodily malfunction) has been the dominant paradigm in pharmacology for about a hundred years.
The drug was able, by selectively interfering with such determinant, to cure the disease and at the same time to keep side effects to a minimum. This strategy worked very well for many years, but around the 1980s it suddenly failed. There was a seeming paradox: basic knowledge in biology boomed, but marketing new drugs plunged. A quite effective hypothesis seems to be the paradigm of 'network pharmacology': the working mechanism is no longer conceived of as a linear chain, it is rather a simultaneous action on several spots of a regulating system. It is supported both through most recent outcomes of systems biology and the experience of success drugs, which are hardly explained by classical receptor mechanisms.
All these topics will be dealt with at the Istituto Superiore di Sanità on 20th November: the meeting will be attended by expert pharmacologists as well as by physicians and engineers who have thoroughly researched the relationships between topology and dynamic behaviour of reticular systems. |
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Program Schedule
Morning Session
09.30 a.m. Greetings from the President of the Istituto Superiore di Sanità, Prof. Enrico Garaci
Short Introduction to the main themes of the congress
Dr. Alessandro Giuliani -- Dept. Environment and Primary Prevention -- Istituto Superiore di Sanità -- Rome Italy
10.00 a.m. "Network Pharmacology: opportunities, promises and challenges of multi-target drug discovery"
Prof. Andrew L. Hopkins FRSC -- Division of Biological Chemistry and Drug Discovery, College of Life Sciences -- University of Dundee, UK
10.30 a.m. "Integrating human and rodent pathophysiology and genetics: a successful drug discovery strategy"
Prof. Giuseppe Bianchi -- Vita-Salute University San Raffaele Hospital, Milano, and Prassis Research Institute Sigma-Tau S.p.A., Italy
11.00 a.m. Coffee break
11.15 a.m. "The Importance of being central"
Prof. Vito Latora -- Assistant Professor in Theoretical Physics at Catania University, Italy
11.45 a.m. "Links, flows and perturbations: systemic responses of biological networks"
Prof. Lorenzo Farina -- Dipartimento di Informatica e Sistemistica -- Università La Sapienza -- Rome, Italy
Afternoon Session
15.00 a.m. "Experimental and regulatory issues in system biology"
Prof. Patrizia Popoli -- Research Director, Head of Central Nervous System Pharmacology section, Department of Therapeutic Research and Medicines Evaluation -- Istituto Superiore di Sanità -- Rome, Italy
15.30 a.m. "Network-based tools in drug-design"
Prof. Peter Csermely -- Semmelweis University, Department of Medical Chemistry -- Budapest, Hungary
16.00 a.m. Coffee break
16.15 a.m. Open Discussion |
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Fondazione
Sigma-Tau - All rights reserved.
