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Monday, November 16, 2009 |
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Bari
Anfiteatro anatomico "L. Giannelli" A.O. Policlinico
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Begins at 16:00 |
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Free admission
The conference will be in English |
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For information:
FONDAZIONE SIGMA-TAU
Viale Shakespeare, 47
00144 Rome
Tel. 06-59.26.443-4-5 06-59.26.600
Fax: 06-59.26.441 |
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MEDICINA DELLA COMPLESSITA' |
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"Ben Van Ommen: Metabolic profiling of the response to an oral Glucose tolerance test detects subtle metabolic changes" |
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Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes
Ben van Ommen
TNO Quality of Life, The Netherlands
The oral glucose tolerance test is used in clinical practice and research to assess the degree of insulin sensitivity by quantifying the plasma glucose clearance. Yet, the impact of this glucose challenge on human physiology goes way beyond this simple observation. Both the glucose metabolism and the effect of the triggered insulin response produce extensive reactions on the level of metabolism, oxidative stress and inflammation.
We have therefore quantified the impact of the OGTT on human physiology using a systems biology approach. In 19 study subjects with mild overweight, 340 metabolites were quantified in plasma during a 3-hour and 6-point time course. Also, 80 inflammation related plasma proteins and the complete PBMC transcriptome were quantified at fasting state. This resulted in a very comprehensive overview of metabolic, regulatory and physiological changes, comprising triglyceride, fatty acid and amino acid metabolism, ketone bodies, oxidative stress defense, inflammatory signaling, and many other processes. On the one hand, this resulted in extensive "textbook biochemistry", but on the other hand revealed many subtleties in individual differences in response. These will be discussed during the lecture.
In a broader perspective, the concept of challenging homeostasis to quantify health is receiving increasing attention. With the growing need for preventive medicine and substantiated health claims for food products to maintain optimal health, a new generation of biomarkers is needed that does not describe a (pre)pathological state but indeed quantifies optimal health by quantifying the perturbation of homeostasis. The OGTT is a classical example of such a biomarker. These concepts and examples will also be discussed. |
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Prof. Ben VAN OMMEN
Department Quality of Life, TNO, Zeist, the Netherlands
Coordinators:
Prof. Francesco Giorgino
Full professor of Endocrinology and Metabolic diseases, Università degli Studi di Bari, Director of the Unità operativa Complessa di endocrinologia, Azienda Ospedaliera-Universitaria Policlinico Consorziale, Bari
Prof. Mauro Cignarelli
Full professor of Endocrinology and Metabolic diseases, Università degli Studi di Foggia, Head of the Postgraduate School in Endocrinology and Metabolic diseases
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Fondazione
Sigma-Tau - All rights reserved.
